Education
University of California, Irvine, Ph.D. 1991
Biography
Dr. Lallier received his Bachelor of Arts degree in Biology from the University of
Virginia in 1985. He received his PhD in Developmental and Cell Biology from the University
of California at Irvine in 1991. Dr. Lallier conducted postdoctoral training in the
laboratory of Douglas Desimone in the Department of Cell Biology at the University
of Virginia School of Medicine. He accepted a position of assistant professor in the
Department of Cell Biology and Anatomy at LSUHSC in 1997, when he joined the Center
of Excellence in Oral and Craniofacial Biology. He was promoted to associate professor
in 2002.
Research Interests
Our lab investigates the interaction of aging, smoking and alcohol use on tissue remodeling.
We are currently using an in vitro model system to examine how these factors influence cell adhesion, cell motility and
the ability of these cells to exert contractile forces on collagen gels. In this system
we are examining extracellular matrix (ECM) synthesis and secretion (of collagens
and other matrix glycoproteins and proteoglycans), cell-ECM receptors (integrins)
and matrix metalloproteinases (MMPs). Our system focuses on gingival and periodontal
ligament fibroblasts as a means to examine the reparative properties of connective
tissue cells on tissue regeneration. Our current findings indicate that aging selectively
reduces the expression of several collagens and MMPs, reducing collagen gel contraction
and cell motility without perturbing cell adhesion. In addition, nicotine drastically
reduces gel contraction, without altering integrin expression. Finally, aging enhances
the sensitivity of cells for nicotine, inducing significant alteration in ECM receptor
(integrin) expression. Taken together, these data indicate that smoking and alcohol
use may have an additive (or even synergistic) ability to reduce the reparative capabilities
of cells in older subjects.
Research Interests--Keywords
Periodontal ligament, gingival, fibroblast, extracellular matrix, tissue remodeling,
tobacco, cigarette smoke
Teaching Activities
General Histology – Dental - Course Director
Oral Histology – Dental - Course Director
General and Oral Histology – Dental Hygiene - Course Director
Cell and Molecular Biology – Graduate - Course Director
Advanced Biophysiology – Dental Residents – Course Director
Science and Practice of Medicine – Medical – Group Leader
Selected Publications
Accardo, C., Himel, V.T., and Lallier, T.E. (2013). A Novel GuttaFlow Sealer Supports Cell Survival and Attachment. JOE (Accepted
2013-0828).
Mitchell, Q., Jeansonne, B.G., Stoute, D., and Lallier, T.E. (2013). Electrochemical Dissolution of NiTi Endo Files Induces PDL Cell Death. J Endodontics
39(5):679-84
Wang, Y., Samoei, G.K., Lallier, T.E., and Xu .X. (2013). Synthesis and Characterization of New Antibacterial
Fluoride-Releasing Monomer and Dental Composite ACS Macro Letters. 2(1):59-62.
Fan, Y., Wen, Z.T., Sun, Z., Hagan, J.L, Lallier, T., Liao, S., Xu, X. (2013). Novel amelogenin-releasing hydrogel for remineralization
of enamel artificial caries. J Bioact Compat Polym. 27(6):585-603.
Tsourounakis, I., Palaiologou, A., Stoute, D., Maney, P., Lallier, T.E. (2013). Dilute Essential Oil Mouthwashes Promote Gingival Fibroblast Migration. J.
Periodontology. Aug;84(8):1211-20
Macway, S., Lallier, T.E. (2013). Pedialyte® promotes periodontal ligament cell survival and motility. J Endodontics
39(2) 202-207
Palaiologou, A., Stoute, D., Fan, Y. and Lallier, T.E. (2012). Modifications of Titanium Surfaces Alter Periodontal Cell Attachment and Motility.
J. Periodontology. 83:1 90-100
Bulmanski, Z., Brady, M. Stoute, D., and Lallier, T.E. (2012). Cigarette Smoke Extract Induces Select MMP and Integrin Expression in Periodontal
Ligament Fibroblasts. J Periodontology 83(6):787-96
Wu, R., Zhang, J.F., Fan, Y., Stoute, D., Lallier, T.E., and Xu, X. (2011) Reactive electrospinning and biodegradation of cross-linked
methacrylated polycarbonate nanofibers. Biomedical Materials 6 (3):035004