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Comprehensive Dentistry & Biomaterials

Department of Oral and Craniofacial Biology
Xiaoming Xu, Ph.D., Professor

Professor
Comprehensive Dentistry and Biomaterials
Head, Division of Biomaterials
Director of Biomaterials Research

Office: Jeansonne Clinic Building
Room #6349
Email:xxu@lsuhsc.edu
Phone: 504-941-8265  Fax: 504-941-8265

The Division of Biomaterials in the Department of Comprehensive Dentistry and Biomaterials is responsible for teaching and research in biomaterials and dental materials. An advanced dental materials course is offered to residents and fellows. The division supports Advanced Education programs and the research activities of faculty, students, and residents in the school. It has several laboratories located on the sixth and eighth floors of the Clinic Building in the LSUHSC School of Dentistry, with a total space of over 3000 square feet. The laboratories are equipped with state-of-the-art analytical and testing instruments (see list of major equipment). Currently the division has two faculty members, Dr. Xu and Dr. Wen, and three research associates.

Biography

Dr. Xiaoming Xu obtained his BS degree in 1981 and Master’s degree 1984, both in Metallurgical Engineering from Central South University in China. He obtained his Ph.D. degree in Chemistry in 1996 from University of New Orleans. He was trained under Dr. John Burgess as postdoctoral research associate in Dental Materials at Louisiana State University Health Sciences Center, School of Dentistry. He joined the faculty of this school in 2001. He was promoted to Associate Professor with tenure and appointed as Director of Biomaterials Research in 2006. Dr. Xu was appointed as Head, Division of Biomaterials in 2009 and was awarded the Jack Sheridan Endowed Professorship in 2009. He was promoted to full professor in 2011.

Research Interests

Dr. Xu’s primary research interest is in dental materials and biomaterials, include dental composites, nanocomposites, sealants, bonding agents, cements, and scaffolds for tissue engineering. The focus of the research is to develop novel dental and biological materials that have functionalities of caries-inhibiting, antibacterial, or remineralization as well as excellent physical and mechanical properties.

Funded by a NIH/NIDCR R01 grant, Dr. Xu’s current major research project is “High performance antibacterial fluoride-releasing dental materials”. Tooth decay (dental caries) is the most prevalent chronic oral disease. The current treatment is to remove the decayed tooth tissues and restore teeth with filling materials such as dental composites. Currently, composite restorations have a limited service life (5-7 years) and their replacement accounts for 60% of dental operations. The leading cause for the failure of composite restorations is the development of secondary caries caused by bacterial biofilms at the restoration margin. Although much effort has been directed towards the development of dental materials that can inhibit bacterial biofilms and reduce secondary cavities, most have had either poor mechanical properties or an unacceptable, dark shade, such as silver-containing materials. Dr. Xu’s group has been developing a series of novel antibacterial fluoride-releasing materials (dental composites, bonding agents and sealants) that have shown enhanced fluoride-releasing and recharge capabilities, promising antibacterial effect, and good physicomechanical properties or bonding strength. This new grant will support further development of these promising materials. The researchers will test a combination of new technologies such as antibacterial monomers with different chain lengths and nanoparticles for controlled release of antibacterial agents in response to pH values. The long-term goal is to develop a new generation of dental materials that have a high efficacy to inhibit oral biofilm formation as well as excellent physical and mechanical properties.

Another major aspect of Dr. Xu’s research is the fabrication of functional and crosslinked polymer nanofibers for tissue engineering and other biological applications. Dr. Xu has developed a novel technology called “Reactive Electrospinning”, which combines electrospinning with in situ chemical or photochemical reactions. This technology can produce cross-linked microfibers and nanofibers with different functionalities such as hydrophilic yet water-insoluble, chelating, or antimicrobial. Such novel materials may potentially have wide applications in tissue engineering and regenerative medicine.

Dr. Xu’s lab also conduct in vitro tests and evaluation of dental materials and biomaterials for their  mechanical properties, bonding strength , wear and surface roughness, thermal properties, hardness, fracture toughness , polymerization shrinkage, color stability, and translucency. These research projects are often collaborated with dental materials manufacturers. They also provide opportunity for students and residents research.

Research Interests--Keywords
Dental materials, composites, bonding agents, sealants, biofilms, caries, nanofibers, electrospinning.

Teaching Activities
Advanced Dental Materials Science, Research Methodologies, and Dental Grand Rounds

Selective Publications

Yapin Wang, Stephen Costin, Jian-Feng Zhang, Sumei Liao, Zezhang T. Wen, Thomas Lallier, Qingzhao Yu, Xu, X. Synthesis, antibacterial activity, and biocompatibility of new antibacterial dental monomers. Am J Dent 2018; 31(Sp Is B):17B-23B.

Song Hong, Yan Lu, Masao Morita, Shun Saito, Yuichi Kobayashi, Bokkyoo Jun, Nicolas G. Bazan, Xiaoming Xu, Yapin Wang. Stereoselective Synthesis of Maresin-Like Lipid Mediators, SynLett, 2019, 30, 343–347. DOI: 10.1055/s-0037-1612011.

Mesa TR, Xu X, Cehreli ZC, Founier SE, Brashier CT, Yu Q., Townsend JA. Effect of Light Cure Methods for Intermediate Adhesive Layer on Microleakage of Sealants. An in vitro Study. The Journal of Clinical Pediatric Dentistry. 2019 43 (4) 262-267 DOI:10.17796/1053-4625-43.4.7.

Herman JL, Wang Y, Lilly E, Lallier T, Hamdan S, Xu, X, Fidel PL Jr, Noverr MC. Synthesis, Antifungal Activity, and Biocompatibility of novel DABCO Compounds and DABCO- containing Denture Base Resins. Antimicrobial Agents and Chemotherapy. 2017, 61(4) e02575-16.

Epperson M, Vazirani N, Armbruster PC, Kee EL, Xu, X, Ballard RW. Hybrid Crowns – Bonding Protocols and Shear Bond Strength Austrailian Orthodontic Journal. 2017;33:40-47

Lestrade A, Ballard R, Xu X, Yu Q, Kee E, Armbruster P. Porcelain Surface Conditioning Protocols and Shear Bond Strength of Orthodontic Brackets on the Posterior Dentition.  Australian Orthodontic Journal. 2016;32:18-22.

Xiao Y, Gong T, Jiang Y, Wang Y, Wen ZT, Zhou S, Bao C, Xu, X. Fabrication and characterization of a glucose-sensitive antibacterial chitosane polyethylene oxide hydrogel. Polymer 2016, 82, 1-10.

 

 

 

 

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