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Comprehensive Dentistry & Biomaterials

Department of Oral and Craniofacial Biology
Xiaoming Xu, Ph.D., Professor

Professor
Comprehensive Dentistry and Biomaterials
Head, Division of Biomaterials
Director of Biomaterials Research

Office: Jeansonne Clinic Building
Room #6349
Email:xxu@lsuhsc.edu
Phone: 504-941-8265  Fax: 504-941-8265

The Division of Biomaterials in the Department of Comprehensive Dentistry and Biomaterials is responsible for teaching and research in biomaterials and dental materials. An advanced dental materials course is offered to residents and fellows. The division supports Advanced Education programs and the research activities of faculty, students, and residents in the school. It has several laboratories located on the sixth and eighth floors of the Clinic Building in the LSUHSC School of Dentistry, with a total space of over 3000 square feet. The laboratories are equipped with state-of-the-art analytical and testing instruments (see list of major equipment). Currently the division has two faculty members, Dr. Xu and Dr. Wen, and three research associates.

Biography

Dr. Xiaoming Xu obtained his BS degree in 1981 and Master’s degree 1984, both in Metallurgical Engineering from Central South University in China. He obtained his Ph.D. degree in Chemistry in 1996 from University of New Orleans. He was trained under Dr. John Burgess as postdoctoral research associate in Dental Materials at Louisiana State University Health Sciences Center, School of Dentistry. He joined the faculty of this school in 2001. He was promoted to Associate Professor with tenure and appointed as Director of Biomaterials Research in 2006. Dr. Xu was appointed as Head, Division of Biomaterials in 2009 and was awarded the Jack Sheridan Endowed Professorship in 2009. He was promoted to full professor in 2011.

Research Interests

Dr. Xu’s primary research interest is in dental materials and biomaterials, include dental composites, nanocomposites, sealants, bonding agents, cements, and scaffolds for tissue engineering. The focus of the research is to develop novel dental and biological materials that have functionalities of caries-inhibiting, antibacterial, or remineralization as well as excellent physical and mechanical properties.

Funded by a NIH/NIDCR R01 grant, Dr. Xu’s current major research project is “High performance antibacterial fluoride-releasing dental materials”. Tooth decay (dental caries) is the most prevalent chronic oral disease. The current treatment is to remove the decayed tooth tissues and restore teeth with filling materials such as dental composites. Currently, composite restorations have a limited service life (5-7 years) and their replacement accounts for 60% of dental operations. The leading cause for the failure of composite restorations is the development of secondary caries caused by bacterial biofilms at the restoration margin. Although much effort has been directed towards the development of dental materials that can inhibit bacterial biofilms and reduce secondary cavities, most have had either poor mechanical properties or an unacceptable, dark shade, such as silver-containing materials. Dr. Xu’s group has been developing a series of novel antibacterial fluoride-releasing materials (dental composites, bonding agents and sealants) that have shown enhanced fluoride-releasing and recharge capabilities, promising antibacterial effect, and good physicomechanical properties or bonding strength. This new grant will support further development of these promising materials. The researchers will test a combination of new technologies such as antibacterial monomers with different chain lengths and nanoparticles for controlled release of antibacterial agents in response to pH values. The long-term goal is to develop a new generation of dental materials that have a high efficacy to inhibit oral biofilm formation as well as excellent physical and mechanical properties.

Another major aspect of Dr. Xu’s research is the fabrication of functional and crosslinked polymer nanofibers for tissue engineering and other biological applications. Dr. Xu has developed a novel technology called “Reactive Electrospinning”, which combines electrospinning with in situ chemical or photochemical reactions. This technology can produce cross-linked microfibers and nanofibers with different functionalities such as hydrophilic yet water-insoluble, chelating, or antimicrobial. Such novel materials may potentially have wide applications in tissue engineering and regenerative medicine.

Dr. Xu’s lab also conduct in vitro tests and evaluation of dental materials and biomaterials for their  mechanical properties, bonding strength , wear and surface roughness, thermal properties, hardness, fracture toughness , polymerization shrinkage, color stability, and translucency. These research projects are often collaborated with dental materials manufacturers. They also provide opportunity for students and residents research.

Research Interests--Keywords
Dental materials, composites, bonding agents, sealants, biofilms, caries, nanofibers, electrospinning.

Teaching Activities
Advanced Dental Materials Science, Research Methodologies, and Dental Grand Rounds

Selective Publications

Herman JL, Wang Y, Lilly E, Lallier T, Hamdan S, Xu X, Fidel PL Jr, Noverr MC. Synthesis, Antifungal Activity, and Biocompatibility of novel DABCO Compounds and DABCO- containing Denture Base Resins. Antimicrobial Agents and Chemotherapy. 2017, 61(4) e02575-16.

Epperson M, Vazirani N, Armbruster PC, Kee EL, Xu X, Ballard RW. Hybrid Crowns – Bonding Protocols and Shear Bond Strength Austrailian Orthodontic Journal. 2017;33:40-47

Lestrade A, Ballard R, Xu X, Yu Q, Kee E, Armbruster P. Porcelain Surface Conditioning Protocols and Shear Bond Strength of Orthodontic Brackets on the Posterior Dentition.  Australian Orthodontic Journal. 2016;32:18-22.

Xiao Y, Gong T, Jiang Y, Wang Y, Wen ZT, Zhou S, Bao C, Xu X. Fabrication and characterization of a glucose-sensitive antibacterial chitosane polyethylene oxide hydrogel. Polymer 2016, 82, 1-10.

Zheng J, Xiao Y, Gong T, Zhou S, Troczynski T, Yang Q, Bao C, Xu X. Fabrication and characterization of a novel carbon fiber-reinforced calcium phosphate silicate bone cement with potential osteo-inductivity. Biomedical Materials. 2015,11(1):015003. (doi: 10.1088/1748-6041/11/1/015003).

Zhou Y, Xiao Y, Qiu Y, Yuan H, van Blitterswijk CA, Zhou X, Xu X, Bao C Adhesion and proliferation of cells and bacteria on microchip with different surfaces microstructures. Biomed Tech (Berl). 2015 Dec 18. doi: 10.1515/bmt-2015-0075. [PMID: 26684347]

Nhan RTH, Xu X, Yu Q, Ballard R, Armbruster P. The effect of topical fluoride varnish on the

shear bond strength of orthodontic brackets. Australian Orthodontic Journal, 2015; 31:14–19.

 

Li S, Zhang JF, Chen J, Chen Y, Zhao X, Xu X. Core-sheath zirconia/silica microfibers for dental composites reinforcement, Materials Letters, 2015, 142(3): 204–206

Zhang JF, Wu R, Fan Y, Liao S, Wang Y, Wen ZT, Xu X. Antibacterial Dental Composites with Chlorhexidine and Mesoporous Silica, Journal of Dental Research, 2014 93(12): 1283-1289.

Townsend JA, Knoell P, Yu Q, Zhang JF,  Wang Y,  Zhu H, Beattie S, Xu X. In Vitro Fracture Resistance of Three Commercially Available Zirconia Crowns for Primary Molars. Pediatric Dentistry, 2014, 36 (5):E125-E129

Fan Y, Townsend J, Wang Y, Lee E-C, Evans K, Hender E, Hagan JL, and Xu X. Formulation and characterization of antibacterial fluoride-releasing sealants. Pediatric Dentistry 2013, 35 (1) E414-419.  [PMCID: PMC3644993]

Wang Y, Samoei GK, Lallier TE and Xu X. Synthesis and Charaterization of New Antibacterial Fluoride-releasing Monomer and Dental Composite. ACS Maco Letters 2012, 2(1):59-62. [PMCID: PMC3546533]

Fan Y, Wen ZT, Liao S, Lallier T, Hagan JL, Twomley JT, Zhang JF, Sun Z, Xu X. Novel amelogenin-releasing hydrogel for remineralization of enamel artificial caries. Journal of Bioactive and Biocompatible Polymers 2012, 27(6):585-603.   [PMCID: PMC3548329]

Xu X and Zhang JF. Cross-linked electrospun fibrous scaffolds for tissue engineering. Current Tissue Engineering 2012, 1, 2-14.

Xu X, Wang Y, Liao S, Wen ZT, Fan Y. Synthesis and Characterization of Antibacterial Dental Monomers and Composite, Journal of Biomedical Materials Research, Part B – Applied Materials 2012, 100B:1151-1162. [PMCID: PMC3407682]

Guo G, Fan Y, Zhang JF, Hagan J, and Xu X. “Novel Dental Composites Reinforced with Zirconia-Silica Ceramic Nanofibers”, Dental Materials 2012, 28(4), 360-368. [PMCID: PMC3299838].

Wu R, Zhang JF, Fan Y, Stoute D, Lallier T and Xu X. Reactive electrospinning and biodegradation of cross-linked methacrylated polycarbonate nanofibers. Biomedical Materials 2011, 6, 035004 (13pp).

Fan Y, Nelson JR, Alvarez JR, Hagan J, Berrier A, Xu X. Amelogenin-assisted ex vivo remineralization of human enamel: effects of supersaturation degree and fluoride concentration. Acta Biomateriala 2011, 7:2293-2302.

Xu X, Zhang JF, Fan Y. Fabrication of Cross-Linked Polyethyleneimine Microfibers by Reactive Electrospinning with In Situ Photo-Cross-Linking by UV Radiation. Biomacromolecules, 2010, 11 (9):2283–2289.

Xu X, Guo G, and Fan Y. Fabrication and Characterization of Dense Zirconia and Zirconia-Silica Ceramic Nanofibers. Journal of Nanoscience and Nanotechnology 2010; 10(9) 5672-5679. [PMCID: PMC3181101].

Ling L, Xu X, Choi GY, Billodeaux D, Guo G., and Diwan RM. Novel F-releasing composite with improved mechanical properties Journal of Dental Research 2009; 88(1):83-88.

Xu X, Wang R, Ling L, and Burgess JO. Synthesis and Stability Study of Dental Monomers Containing Methacrylamidoethylphosphonic Acid. Journal of Polymer Science A: Polymer Chemistry 2007; 45:99-110.

Xu X, Ling L, Wang R, and Burgess JO. Formulation and characterization of a novel fluoride-releasing dental composite. Dental Materials 2006, 22(11): 1014-1023.

Xu X, Sandras D, Burgess, JO. Shear Bond Strength with increasing light guide distance from dentin. Journal of Esthetic and Restorative Dentistry 2006, 18:19-28.

Xu X, Ding X, Ling L, and Burgess JO. Synthesis and Characterization of Novel Fluoride-Releasing Monomers 2: Dimethacrylates Containing Bis(aminodiacetic acid) and Their Ternary Zirconium-Fluoride Complexes. Journal of Polymer Science A: Polymer Chemistry 2005, 43, 3135-3166

X. Xu, L. Ling, X. Ding, J. O. Burgess. Synthesis and Characterization of a Novel, Fluoride-Releasing Dimethacrylate Monomer and Its Dental Composite. Journal of Polymer Science:  Part A:  Polymer Chemistry, 2004; 42:985-995.

Xu X, Burgess JO. Compressive Strength, Fluoride Release and Recharge of Fluoride-releasing Materials. Biomaterials 2003; 24:2451-2461.



Click here for a list of full-time faculty members in the Division of Biomaterials.

 

 

 

 

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