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Comprehensive Dentistry & Biomaterials

Department of Oral and Craniofacial Biology
Mairi C. Noverr, Ph.D., Professor

 Professor, Prosthodontics
Adjunct Professor, Microbiology, Immunology & Parasitology

Office: Jeansonne Clinic Building
Room #8405A
Email: mnover@lsuhsc.edu
Phone: 504-941-8055  Fax: 504-941-8098

Education
University of Michigan, Ph.D. 2002

Biography

 Dr. Noverr received her Bachelor of Arts in Biology from Kalamazoo College in Michigan in 1996. She then received her Ph.D. in Microbiology and Immunology from the University of Michigan in 2002. Dr. Noverr trained as a post-doctoral fellow in the laboratory of Dr. Gary Huffnagle at the University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine. Subsequently she accepted a position as Assistant Professor of Immunology and Microbiology at Wayne State University School of Medicine in 2005. Dr. Noverr came to LSUHSC in 2009 as an Associate Professor in the Department of Oral and Craniofacial Biology, and was promoted to the rank of Full Professor in the Department of Prosthodontics in 2016. 

 

Research interests:

 Dr. Noverr’s research program is funded by R01 grants from the NIH-NIAID and the NIDCR. Her current research focuses on investigating mechanisms of immunomodulation by the opportunistic yeast Candida albicans during host-pathogen interactions.  The majority of humans are chronically colonized at various mucosal surfaces with C. albicans.  This fungal pathogen causes a range of health problems, ranging from systemic fungal infection to superficial hypersensitivity responses.

 The overall goal of the laboratory is to characterize mechanisms of Candida persistence within the host and how this contributes to the shift from a commensal to a pathogen.  Projects in the laboratory include determining the effects of host eicosanoids and fungal oxylipins during Candida pathogenesis, in modulating host immune cell function, and in Candida morphogenesis and biofilm formation, both monomicrobial and polymicrobial. More recently we have developed a polymicrobial intra-abdominal infection model with C. albicans and Staphylococcus aureus, two pathogens that inhabit the same niches in the host, and that cause synergistic effects on mortality. Investigation of the host response revealed a key role for PGE2 in promoting inflammation and mortality, which brings the focus back to a key strength of the laboratory, eicosanoid research (focus of current NIAID R01).  In addition, the laboratory is investigating novel in vivo models of biofilm formation at mucosal surfaces, both during experimental vaginitis and denture stomatitis (focus of current NIDCR R01).  These models allow investigation of host, bacterial, and fungal factors that affect Candida biofilms in a clinically relevant setting. Her laboratory also regularly collaborates with other faculty at LSU including projects focused on vulvovaginal candidiasis (VVC) and innate dysfunction (Dr. Paul Fidel, COE Director), and efficacy of novel denture biomaterials impregnated with antifungal agents (Dr. Xiaoming Xu, Dept. of Biomaterials).

 

Research Interests--Keywords 
Candida albicans, candidiasis, polymicrobial, biofilms, Staphylococcus aureus, sepsis, eicosanoids, patahogenesis, mucosal infection

 

Teaching activities:

Honors in Research

Advanced Ed Research Methodology
Advanced Ed Immunology

Undergraduate Microbiology & Immunology

 

Selected Publications

 Herman, JL, Wang, Y, Lilly, EA, Lallier, T, Hamdan, S, Xu, X, Fidel, PL, and MC Noverr.  2017. Antifungal Activity of Novel Synthesized Antimicrobial Compounds Solubilized and Incorporated into Denture Base Resins. Antimicrob. Agents. Chemother. 61: e02575-16.

 Yano, J, Noverr, MC, and PL Fidel.  2017. Vaginal heparan sulfate linked to neutrophil dysfunction in the acute inflammatory response associated with experimental vulvovaginal candidiasis. MBio 14:8(2).

 Jabra-Rizk, MA, Kong, EF, Tsui, C, Nguyen, MH, Clancy, CJ, Fidel, PL, and MC Noverr. 2016. Candida albicans pathogenesis: Fitting within the “Host-Microbe Damage Response Framework”. Infect. Immun. 84:2724-39

 Yano, J, Yu, A, Fidel, PL, and MC Noverr.  2016.  Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis. PLoS One 11:e0159692.

 Nash EE, Peters, BM, Lilly, EE, Noverr, MC, and PL Fidel.  2016.  A Murine Model of Candida glabrata Vaginitis Shows No Evidence of an Inflammatory Immunopathogenic Response.  PLoS One 11:e0147969.

 Nash EE, Peters BM, Fidel PL, and MC Noverr. 2015.  Morphology-independent virulence of Candida species during polymicrobial intra-abdominal infections with Staphylococcus aureus. Infect. Immun. 84:90-8.

 Bruno VM, Shetty AC, Yano J, Fidel PL Jr, Noverr MC, Peters BM. 2015.  Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome. MBio. Apr 21;6(2).

Peters BM, Palmer GE, Fidel PL Jr, Noverr MC. 2014.  Fungal morphogenetic pathways are required for the hallmark inflammatory response during Candida vaginitis. Infect. Immun. 82:532-43.

 Nash, EK, Peters, BM, Palmer, GE, Fidel, PL Jr, and Noverr, MC.  2014.  Morphogenesis is not required for Candida albicans-Staphylococcus aureus intra-abdominal infection-mediated dissemination and lethal sepsis.  Infect. Immun. 82:3426-35.

 Peters, BP, Ward, RM, Rane, HS, Lee, SA, and MC Noverr.  2013.  Efficacy of ethanol against Candida albicans and Staphylococcus aureus polymicrobial biofilms.  Antimicrob. Agents Ch. 57:1736-43.

Peters, BP, and MC Noverr. 2013. Candida albicans-Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity.  Infect. Immun. 81:2178-89. 
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