of Michigan, Ph.D. 2002
Dr. Noverr received her
Bachelor of Arts in Biology from Kalamazoo
College in Michigan in 1996. She then received
her Ph.D. in Microbiology and Immunology from
the University of Michigan in 2002. Dr. Noverr
trained as a post-doctoral fellow in the
laboratory of Dr. Gary Huffnagle at the
University of Michigan Medical School, Division
of Pulmonary and Critical Care Medicine.
Subsequently she accepted a position as
assistant professor of Immunology and
Microbiology at Wayne State University School of
Medicine in 2005. Dr. Noverr came to LSUHSC in
2009 as an associate professor in the Department
of Oral and Craniofacial Biology.
Dr. Noverr’s research program is currently
funded by two R01 grants from the NIH-NIAID and
current research focuses on investigating
mechanisms of immunomodulation by the
opportunistic yeast Candida albicans
during host-pathogen interactions.
The majority of
humans are chronically colonized at various
mucosal surfaces with C. albicans. This
fungal pathogen can cause a variety of
infections, ranging from mucosal to systemic and
The overall goal of
the laboratory is to characterize mechanisms of
Candida persistence within the host and
how this contributes to the shift from a
commensal to a pathogen.
Dr. Noverr’s current NIAID funded research is
focused on investigating immunomodulatory fungal
compounds that influence innate and adaptive
immune responses. Previous work by Dr. Noverr
revealed that C. albicans produces
immunomodulatory oxylipins that are similar in
function to host eicosanoids. These fungal
oxylipins not only can influence the host immune
response, but also alter the microbiology of the
fungus, promoting morphogenesis and biofilm
formation. Projects include molecular
characterization of the fungal oxylipin
biosynthetic pathways and determining the
effects of host eicosanoids and fungal oxylipins
during Candida pathogenesis, in
modulating host immune cell function, and in
Candida morphogenesis and biofilm formation,
both monomicrobial and polymicrobial.
newly funded project from the NIH-NIDCR is
focused on investigating Candida
associated denture stomatitis (DS), a common oral
mucosal infection. The major goals of this
grant are to determine the role of monomicrobial
and polymicrobial biofilm formation in
Candida-associated DS and characterize host
response parameters that influence the
development of disease using a novel innovative
rat model of DS.
This model will also allow investigation of host,
bacterial, and fungal factors that affect
Candida biofilms in a clinically relevant
albicans, Candidiasis, Biofilms, Oxylipins,
School of Dentistry:
Honors in Research
Advanced Education: Immunology
Undergraduate Education: Microbiology &
School of Medicine:
Ward, RM, Rane, HS, Lee, SA, and MC Noverr.
2012. Efficacy of ethanol against Candida
albicans and Staphylococcus aureus polymicrobial
biofilms. Antimicrob. Agents Ch. In Press.
Yu, A, Lee, H, Fidel Jr, PL, and MC Noverr.
2012. Development of a contemporary animal
model of Candida-associated denture stomatitis
using a novel intraoral denture system. Infect.
Lee, H, Yu, A,
Johnson, CC, Lilly, EA, Noverr, MC, and
PL Fidel Jr. 2011. Fabrication of a
multi-applicable removable intraoral denture
system for rodent research. J. Oral Rehab.
Kundu, G, and
MC Noverr. 2010. Exposure to Host or
Fungal PGE2 Abrogates Protection
Following Immunization with Candida-Pulsed
Dendritic Cells. Med. Mycol. 49:380-94.
and MC Noverr. 2010. Ability of Candida
albicans Mutants to Induce Staphylococcus aureus
Vancomycin Resistance During Polymicrobial
Biofilm Formation. Antimicrob. Agents Ch.
Lilly, EA, Rodriguez, TE, Fidel Jr, PL, and
MC Noverr. 2010. Candida albicans
forms biofilms on vaginal epithelium.
and MC Noverr. 2009. Candida albicans
and Staphylococcus aureus Form
Polymicrobial Biofilms with Increased Antibiotic
Resistance. Antimicrob. Agents Ch.
Huffnagle, GB, and MC Noverr. 2008. The
“Microbiota Hypothesis” of Allergic Disease. In
GI Microbiota and Regulation of the Immune
System. Landes Bioscience.
JR, and MC Noverr. 2007.
Characterization of prostaglandin E2 production
by Candida albicans. Infect. Immun.