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Comprehensive Dentistry & Biomaterials

Department of Oral and Craniofacial Biology
Mairie C. Noverr, Ph.D., Associate Professor

Associate Professor, Prosthodontics
Adjunct Professor, Microbiology, Immunology & Parasitology

Office: Jeansonne Clinic Building
Room #8405A
Email: mnover@lsuhsc.edu
Phone: 504-941-8055  Fax: 504-941-8098

Education
University of Michigan, Ph.D. 2002

Biography
Dr. Noverr received her Bachelor of Arts in Biology from Kalamazoo College in Michigan in 1996. She then received her Ph.D. in Microbiology and Immunology from the University of Michigan in 2002. Dr. Noverr trained as a post-doctoral fellow in the laboratory of Dr. Gary Huffnagle at the University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine. Subsequently she accepted a position as assistant professor of Immunology and Microbiology at Wayne State University School of Medicine in 2005. Dr. Noverr came to LSUHSC in 2009 as an associate professor in the Department of Oral and Craniofacial Biology.

Research Interests
Dr. Noverr’s research program is currently funded by two R01 grants from the NIH-NIAID and the NIH-NIDCR. 

Dr. Noverr’s current research focuses on investigating mechanisms of immunomodulation by the opportunistic yeast Candida albicans during host-pathogen interactions.  The majority of humans are chronically colonized at various mucosal surfaces with C. albicans. This fungal pathogen can cause a variety of infections, ranging from mucosal to systemic and invasive Candidiasis.   The overall goal of the laboratory is to characterize mechanisms of Candida persistence within the host and how this contributes to the shift from a commensal to a pathogen. 

Dr. Noverr’s current NIAID funded research is focused on investigating immunomodulatory fungal compounds that influence innate and adaptive immune responses. Previous work by Dr. Noverr revealed that C. albicans produces immunomodulatory oxylipins that are similar in function to host eicosanoids.  These fungal oxylipins not only can influence the host immune response, but also alter the microbiology of the fungus, promoting morphogenesis and biofilm formation.  Projects include molecular characterization of the fungal oxylipin biosynthetic pathways and determining the effects of host eicosanoids and fungal oxylipins during Candida pathogenesis, in modulating host immune cell function, and in Candida morphogenesis and biofilm formation, both monomicrobial and polymicrobial.

A newly funded project from the NIH-NIDCR is focused on investigating Candida associated denture stomatitis (DS), a common oral mucosal infection.  The major goals of this grant are to determine the role of monomicrobial and polymicrobial biofilm formation in Candida-associated DS and characterize host response parameters that influence the development of disease using a novel innovative rat model of DS.  This model will also allow investigation of host, bacterial, and fungal factors that affect Candida biofilms in a clinically relevant setting. 

Research Interests--Keywords
Candida albicans, Candidiasis, Biofilms, Oxylipins, Host-pathogen Interactions

Teaching Activities
School of Dentistry:
Honors in Research
Advanced Education: Immunology
Undergraduate Education:  Microbiology & Immunology

School of Medicine:
Immunology
Microbial Biofilms

Selected Publications
Peters, BP, Ward, RM, Rane, HS, Lee, SA, and MC Noverr.  2012.  Efficacy of ethanol against Candida albicans and Staphylococcus aureus polymicrobial biofilms.  Antimicrob. Agents Ch. In Press. 

Johnson, CC, Yu, A, Lee, H, Fidel Jr, PL, and MC Noverr. 2012.  Development of a contemporary animal model of Candida-associated denture stomatitis using a novel intraoral denture system.  Infect. Immun. 80:1735-43. 

Lee, H, Yu, A, Johnson, CC, Lilly, EA, Noverr, MC, and PL Fidel Jr.  2011.  Fabrication of a multi-applicable removable intraoral denture system for rodent research.  J. Oral Rehab.  38:686-90. 

Kundu, G, and MC Noverr. 2010. Exposure to Host or Fungal PGE2 Abrogates Protection Following Immunization with Candida-Pulsed Dendritic Cells. Med. Mycol.  49:380-94. 

Harriott, MM, and MC Noverr. 2010.  Ability of Candida albicans Mutants to Induce Staphylococcus aureus Vancomycin Resistance During Polymicrobial Biofilm Formation.  Antimicrob. Agents Ch. 54:3746-55. 

Harriott, MM, Lilly, EA, Rodriguez, TE, Fidel Jr, PL, and MC Noverr. 2010. Candida albicans forms biofilms on vaginal epithelium. Microbiology. 156:3635-44.

Harriott, MM, and MC Noverr.  2009. Candida albicans and Staphylococcus aureus Form Polymicrobial Biofilms with Increased Antibiotic Resistance. Antimicrob. Agents Ch. 53(9):3914-22. 

Shreiner, A, Huffnagle, GB, and MC Noverr. 2008.  The “Microbiota Hypothesis”  of Allergic Disease. In GI Microbiota and Regulation of the Immune System.  Landes Bioscience. 

Erb-Downward, JR, and MC Noverr.  2007.  Characterization of prostaglandin E2 production by Candida albicans.  Infect. Immun. 75:3498-505. 

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