of California, Irvine, Ph.D. 1991
Lallier received his Bachelor of Arts degree in
Biology from the University of Virginia in
1985. He received his PhD in Developmental
and Cell Biology from the University of
California at Irvine in 1991. Dr. Lallier
conducted postdoctoral training in the
laboratory of Douglas Desimone in the Department
of Cell Biology at the University of Virginia
School of Medicine. He accepted a position
of assistant professor in the Department of Cell
Biology and Anatomy at LSUHSC in 1997, when he
joined the Center of Excellence in Oral and
Craniofacial Biology. He was promoted to
associate professor in 2002.
Our lab investigates the interaction of aging, smoking and alcohol use on tissue remodeling. We are currently using an in vitro model system to examine how these factors influence cell adhesion, cell motility and the ability of these cells to exert contractile forces on collagen gels. In this system we are examining extracellular matrix (ECM) synthesis and secretion (of collagens and other matrix glycoproteins and proteoglycans), cell-ECM receptors (integrins) and matrix metalloproteinases (MMPs). Our system focuses on gingival and periodontal ligament fibroblasts as a means to examine the reparative properties of connective tissue cells on tissue regeneration. Our current findings indicate that aging selectively reduces the expression of several collagens and MMPs, reducing collagen gel contraction and cell motility without perturbing cell adhesion. In addition, nicotine drastically reduces gel contraction, without altering integrin expression. Finally, aging enhances the sensitivity of cells for nicotine, inducing significant alteration in ECM receptor (integrin) expression. Taken together, these data indicate that smoking and alcohol use may have an additive (or even synergistic) ability to reduce the reparative capabilities of cells in older subjects.
Periodontal ligament, gingival, fibroblast, extracellular matrix, tissue remodeling, tobacco, cigarette smoke
General Histology – Dental - Course Director
Oral Histology – Dental - Course Director
General and Oral Histology – Dental Hygiene - Course Director
Cell and Molecular Biology – Graduate - Course Director
Advanced Biophysiology – Dental Residents – Course Director
Science and Practice of Medicine – Medical – Group Leader
Accardo, C., Himel, V.T., and Lallier, TE. (2013). A Novel GuttaFlow Sealer Supports Cell Survival and Attachment. JOE (Accepted 2013-0828).
Mitchell, Q., Jeansonne, B.G., Stoute, D., and Lallier, T.E. (2013). Electrochemical Dissolution of NiTi Endo Files Induces PDL Cell Death. J Endodontics 39(5):679-84
Wang, Y., Samoei, G.K., Lallier, T.E., and Xu .X. (2013). Synthesis and Characterization of New Antibacterial Fluoride-Releasing Monomer and Dental Composite ACS Macro Letters. 2(1):59-62.
Fan, Y., Wen, Z.T., Sun, Z., Hagan, J.L, Lallier, T., Liao, S., Xu, X. (2013). Novel amelogenin-releasing hydrogel for remineralization of enamel artificial caries. J Bioact Compat Polym. 27(6):585-603.
Tsourounakis, I., Palaiologou, A., Stoute, D., Maney, P., Lallier, T.E. (2013). Dilute Essential Oil Mouthwashes Promote Gingival Fibroblast Migration. J. Periodontology. Aug;84(8):1211-20
Macway, S., Lallier, T.E. (2013). Pedialyte® promotes periodontal ligament cell survival and motility. J Endodontics 39(2) 202-207
Palaiologou, A., Stoute, D., Fan, Y. and Lallier, T.E. (2012). Modifications of Titanium Surfaces Alter Periodontal Cell Attachment and Motility. J. Periodontology. 83:1 90-100
Bulmanski, Z., Brady, M. Stoute, D., and Lallier, T.E. (2012). Cigarette Smoke Extract Induces Select MMP and Integrin Expression in Periodontal Ligament Fibroblasts. J Periodontology 83(6):787-96
Wu, R., Zhang, J.F., Fan, Y., Stoute, D., Lallier, T.E., and Xu, X. (2011) Reactive electrospinning and biodegradation of cross-linked methacrylated polycarbonate nanofibers. Biomedical Materials 6 (3):035004