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Comprehensive Dentistry & Biomaterials

Center of Excellence in Oral and Craniofacial Biology
Paul Fidel, Jr., Ph.D., Carl Baldridge Professor

Associate Dean for Research
Adjunct Professor, Microbiology, Immunology & Parasitology
Director, Center of Excellence in Oral and Craniofacial Biology

Office: Jeansonne Clinic Building
Room #7331A
Email: pfidel@lsuhsc.edu
Phone: 504-941-8425   Fax: 504-941-8319

Education
University of Oklahoma, Ph.D. 1988

Biography
Dr. Fidel received his Bachelor of Science degree in Biology from Allegheny College in Pennsylvania in 1984. He then received his Master of Science and PhD degrees in Microbiology from the University of Oklahoma in 1987 and 1988, respectively. Dr. Fidel conducted postdoctoral training in the lab of Dov Boros in the Department of Immunology and Microbiology at Wayne State University School of Medicine in Detroit. He accepted a position of Assistant Professor in the Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine in 1990. Dr. Fidel came to LSUHSC in 1995 as an associate professor in the Department of Microbiology, Immunology, and Parasitology. He was promoted to professor in 1999 and named the Carl Baldridge Research Professor and Director of the Center of Excellence in Oral and Craniofacial Biology, Associate Dean for Research in 2001. He was named interim chair of the new Department of Oral and Craniofacial Biology in 2007 and permanent chair of the department in 2009. In 2013 Dr. Fidel became course director of the advanced education research methodologies course.

As the Associate Dean of Research and Director of the Center of Excellence, Dr. Fidel also oversees all research conducted at the dental school. He has served as Principal Investigator of a $10.7 million Center of Biomedical Research Excellence (COBRE) grant from the NIH (National Center for Research Resources-NCRR) for the dental school to develop promising junior faculty into independent researchers. He has also served as Principal Investigator of the $3.35 million grant from the LA Board of Regents to establish a South Louisiana Institute of Infectious Disease Research.

Research Interests
The Fidel laboratories have been funded under several sources from the NIH, including the National Institute for Dental and Craniofacial Research (NIDCR) and the National Institute for Allergy and Infectious Diseases (NIAID). Studies in the Fidel laboratory focus on host defense against mucosal infections caused by the fungus, Candida albicans. Research in vaginal candidiasis is in both humans and animal models. The research has recently revealed a paradigm shift away from adaptive immune deficiencies as a cause of infection to innate immune mechanisms playing a role in both susceptibility and resistance to infection. Research in oral candidiasis is focused in HIV-infected individuals. This research is focused on the protective role of CD8 T cells and the role of microbiome in the pathogenesis of disease. In addition oral and vaginal epithelial cell antifungal immune mechanisms are being studied. Finally, the role of vaginal and oral Candida biofilms in the pathogenesis of vaginitis and denture stomatitis is being studied through a collaboration with the Noverr laboratory

Research Interests--Keywords
Mucosal immunology
Mucosal candidiasis
Iimmunopathogenesis of recurrent vaginal or oral
candidiasis
Mucosal microbiome in disease pathogenesis

Selected Publications
Lilly, E.A, J. Yano, and P.L. Fidel, Jr. (2010). Annexin–A1 Identified as the oral epithelial cell anti-Candida effector moiety. Mol Oral Micro. 25:293-304.

Yano, J., E.A. Lilly, M.E. Barousse, and P.L. Fidel, Jr. (2010). Epithelial cell-derived S100 calcium-binding proteins as key mediators in the hallmark acute neutrophil response during Candida vaginitis. (Infect. Immun. 78:5126-513.

Lee, H, A. Yu, C. Johnson, M.C. Noverr, and P.L. Fidel, Jr. (2011). Fabrication of a removable intraoral denture device for rodent models of biofilm research. J. Oral Rehab. 38:686-690.

Quimby, K, E. A. Lilly, M. Zacharek, K. McNulty, J.E. Leigh, J.E. Vazquez, and P.L. Fidel, Jr. (2012) CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis. Oral Dis. 18:153-161.

Yano, J., J.K. Kolls, K.I Happel, F.W. Wormley, Jr., K.L. Wozniak, and P.L. Fidel, Jr., (2012). The acute neutrophil response mediated by S100 alarmins during vaginal candidiasis is independent of the Th17 pathway.  Plos One  7(9) e46311.

Yano, J., M.C. Noverr, and P.L. Fidel, Jr. (2012) Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins. Special issue: Cytokines in fungal immunity. Cytokine 58:118-128.


 

 

 

 

 

 

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